Morphological Characteristics of Drug-loaded Nanoparticles based on Microscope Images Analysis System

作     者：Bohua Feng,College of Medical Information Engineering Guangdong Pharmaceutical University Guangzhou,China Siyuan Mo College of Medical Information Engineering Guangdong Pharmaceutical University Guangzhou,China Liufen Peng College of Medical Information Engineering Guangdong Pharmaceutical University Guangzhou,China Huoyan Xu College of Medical Information Engineering Guangdong Pharmaceutical University Guangzhou,China 

会议名称：《2012 National Conference on Information Technology and Computer Science》

会议日期：2012年

学科分类：08[工学] 080203[工学-机械设计及理论] 0802[工学-机械工程] 

基　　金：supported by China National Natural Science Foundation(30771419 and 30971915) 

关 键 词：component Nanoparticle Microscope Image Analysis Morphological Characteristics 

摘      要：Microscope images analysis of drug carriers was a widely used method for those *** manual measuring and analysis of microscope images were subject to errors,and bad stability of *** microscope images analysis method was combined with computer image processing technique in this research.A new nanoparticle Rot/CMC-g-RA was prepared with chitosan derivate drug carrier CMC-g-RA and botanical drug rotenone （Rot）,and a processing and measuring system for microscope images of those drug-loaded nanoparticles was prepared by Visual C++ *** result showed characteristics measured by the system such as nanoparticles,particle size,area and roundness of Rot/CMC-gRA were close to that measured by dynamic light scattering （DLS） *** a fast,precise and automatic method for measuring and statistic nanoparticles morphometric parameters was developed.