Structural diversity of cytochrome P450 reductase may influence stability of oxyferrous P4502B4
作者单位：Department of Biochemistry ＆ Moleculae BiologyXinxiang Medical University University of Michigan and VA Medical Research center
会议名称：《第十届全国酶学学术讨论会》
会议日期：2011年
学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术]
摘 要：Cytochromes P450s are a ubiquitous superfamily which functions primarily as *** P450 catalysis involves an oxyferrous intermediate[Fe(Ⅱ)O or Fe(Ⅲ)O·]that is derived from the di-oxygen binding to the reduced heme iron to initiate the catalytic *** oxyferrous complex is very labile and temperature *** P4502B4 in the presence of benzphetamine(BP) or tert-butyl hydroxytoluene(BHT) can be reduced and formed oxyferrous P450 *** association of