"The blindman and the lame"——Hmt1 dimer fulfills methylation of histone H3 arginine 2 in trans
作者单位：The State Key Laboratory of Molecular BiologyShanghai Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of Sciences University of Chinese Academy of Sciences
会议名称：《2014年第七届中国模式真菌研讨会》
会议日期：2014年
学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 07[理学]
摘 要：The covalent modifications of residues on histone N-terminal tails play pivotal roles in regulating chromatin structure and *** methylation on histone tails appears to be conserved in diverse organisms including yeast and human,however the enzymes and functions of arginine methylation on histone tails are not well *** Saccharomyces cerevisiae,Hmtl is a primary protein methyltransferase,and catalyzes methylation on various protein substrates including some mRNA-binding proteins and histone H4 arginine *** show here that Hmtl methylates the second arginine on histone H3(H3R2)in *** of H3R2 requires