The small GTPase RAB37 promotesautophagosome formationby recruiting ATG5-12
作者单位：Department of GeneticsCollege of Life SciencesWuhan University
会议名称：《2015中国遗传学会大会》
会议日期：2015年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：Vesicle transport RAB37 ATG5 Autophagy Cancer
摘 要：lntracellular membrane trafficking is essential for eukaryotic cell ***,we show that RAB37,a small GTPase involved in vesicle transport,is a target of ATG5,a key protein required for ***37activation through GTP binding recruits ATG5-12 to isolation membrane and promotes autophagosome *** analysis reveals that GTP-bound RAB37 exhibits enhanced interactions with ATG5-12 and GDP-stabilized mutation impairs the ***37 recruits ATG5-12 to LC3-Ⅱpuncta in a GTP-dependent manner to promote ***,RAB37 vesicles participate in formation of autophagosomes and subsequent autolysosomesupon starvation *** ablation of RAB37 expression decreases autophagy and increases tumour metastasis in vivo,whereas forced RAB37 expression suppresses cell proliferation and tumour *** results identify RAB37 as a master organiser of vesicle transport and autophagosome formation through a molecular link of RAB37,ATG5-12 up to *** findings have broad implications for understanding me role of RAB37 vesicle transport in autophagy and cancer.