Corticofugal influence on thalamic neural activity during acute and chronic pain
会议名称：《中国神经科学学会第四次会员代表大会暨第八届全国学术会议》
会议日期：2009年
学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学]
关 键 词：corticofugal influence thalamus pain c-fos
摘 要：正Objective It has been widely accepted that the sensory information is relayed to the cortex via the *** the other hand,there are nearly ten times as many fibers projecting back from the cortex to the thalamus as there are in the forward direction from thalamus to *** influence of cortical modulation from primary somatosensory cortex（SI） on the thalamic nociceptive relay neurons has been *** of studies have found that cortex may modulate visual, auditory and somatic inputs through the corticothalamic projections,thus to adjust the sensory transmission and precisely process the sensory *** previous study has shown a distinct role for the SI in modulating nociceptive behaviors in rats between acute and chronic pain *** present study was designed to further explore the neural mechanisms underlying the role of somatosensory cortex in modulating acute and chronic *** Using a multiple-channel recording technique,we simultaneously recorded the activity of many single neurons located in the primary somatosensory（SI）,as well as the ventral posterior thalamus（VP） in behaving *** used the rat models of thermal induced acute pain and complete Freund’s adjuvant（CFA） evoked chronic inflammatory pain in this study. Noxious radiant heat was delivered to the rat hind paws on the side contralateral to the recording *** of GABAA agonist or antagonist into SI was employed to alter the activity of SI *** animals received the same volume of *** techniques were also used to examine the functional expression of Fos protein in the VP thalamic *** In the electrophysiological study,we found that microinjection of GABAA agonist significantly decreased the activity of SI as well as VP thalamic neurons in the acute pain *** contrast,there was no change in the neural activity of SI and VP following GABAA agonist injection in the CFA evoked chronic *** res