The clinical value of HE4
作者单位：Cancer Hospital Chinese Academy of Medical Sciences
会议名称：《中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议》
会议日期：2010年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：ovarian carcinoma HE4
摘 要：Objective To investigate the clinical values of Human epididymis protein 4(HE4) in ovarian carcinoma *** To detect the serum concentration of HE4 using ELISA in patients of ovarian carcinoma(OC) group (n=119),borderline ovarian tumor group(n=36),benign ovarian neoplasm group(n=96) and female healthy control group(n=53).Results The receiver operation characteristic (ROC) analysis showed the cut-off was 67.3(the AUC was 0.906,the sensitivity and specificity was 80.7%and 94.6% respectively).The serum level of HE4 in OC group were significantly higher than that in borderline ovarian tumor group,benign ovarian neoplasm group and female healthy control group(U was 1003、978、1125,respectively.P0.05).The level of HE4 was reduced significantly in ovarian patients after surgery therapy(Z was 1.491,respectively, P0.05).Conclusions HE4 is helpful biomarker for ovarian carcinoma diagnosis.