Effect of systemic application of 5-hydroxytryptamine on hypoglossal nerve dischargein anesthetized rats
会议名称：《2015年全国睡眠呼吸学术年会》
会议日期：2015年
学科分类：1002[医学-临床医学] 100217[医学-麻醉学] 10[医学]
关 键 词：Serotonin respiratory neuroplasticity hypoglossal nerve longtermfacilitation protein kinase C
摘 要：The aim of this study is to investigate whether systemic 5-HT can promote long-lastingform of respiratory plasticity in vivo via 5-HT2AR-activated PKC *** and peak amplitude of hypoglossal nerve discharges in anesthetized ratswere compared before and after intravenous injections of different treatments,including saline,5-HT,ketanserin tartrate or *** of 5-HT at asystemic bolus imposed an initial ephemeral inhibition subsequently followed bystriking facilitation,which demonstrates a biphasic manner of hypoglossal nerve outputin anesthetized adult *** facilitatory stage conformed to the reinforcedhypoglossal activity that lasted for more than 60 min after drug *** 5-HT evoked biphasic manner of hypoglossal output and hLTF were 5-HT2A receptordependentand coupled to PKC *** initial inhibition of hypoglossal activitywas associated with no dose ganglion,and the subsequent facilitation was associatedwith carotid *** reactive oxygen species（ROS）formation was triggered in thesystemic 5-HT2-dependent hLTF model in *** expressions of immunofluorescenthistochemistry provide morphological evidence of a 5-HT/5-HT2A receptor coupled toPKC *** conclusion,systemic 5-HT challenge contributes to long-lastingform of respiratory plasticity,and contribute to elicit hLTF or elevated hLTF in animals,which with decreased or even with inhibited peripheral inhibitory *** effectof systemic 5-HT was regulated by a5-HT2AR-activated PKC mechanism.