NGF-induced neuritogenesis is promoted by triptolide independent of MAPKs and PI3K/AKT pathways
作者单位：首都医科大学神经生物学系神经变性病教育部重点实验室
会议名称：《中国生理学会第24届全国会员代表大会暨生理学学术大会》
会议日期：2014年
学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学]
关 键 词：PC12 cells neuronal differentiation neurite outgrowth nerve growth factor(NGF) triptolide
摘 要：Nerve growth factor（NGF）is the essential neurotrophic factor for neuronal development and its functional decline is involved in neurodegenerative ***,we found that triptolide（T10）,an active compound from Traditional Chinese Medicine herb,Tripterygium Wilfordii Hook.f.（TWHF）,coordinately worked with the NGF to form an initial protrusive pattern,and later to maintain proper neurite outgrowth in PC12 *** addition,the protein level of growth associated protein 43（GAP-43）,a cellular marker of neuronal differentiation was also enhanced by T10 treatment on NGF-stimulated PC12 *** mechanical investigation demonstrated that the effect of T10 on NGF-induced neuronal morphogenesis is independent of MAPKs and PI3K/AKT *** data suggest that T10 could be a promising small compound collaborating with NGF to restore neural network,although the exact mechanism is still need to be explored.