USP2a stabilizes MDM4 and facilitates the p53-mediated intrinsic-apoptotic pathway in glioblastoma
会议名称：《2011中华医学会神经外科学学术会议》
会议日期：2011年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：MDM4 USP2a p53 p53Ser46P intrinsic-apoptotic pathway glioblastoma
摘 要：Mouse double minute 4 (MDM4) is a key regulator of p53, whose biological activities depend on either transcriptional function or untranscriptional function in mitochondria. Ubiquitin-specific protease 2a ( USP2a )is a deubiquitinating enzyme,and MDM4 is one substrate of USP2a. We investigated gliobl