Novel High Active Antibacterial Imidazole-Cu2+-MRSA DNA Ternary Supramolecular Complexes
作者单位：School of Chemistry and Chemical Engineering Southwest University Indian Institute of Chemical Technology(IICT)
会议名称：《全国第十七届大环化学暨第九届超分子化学学术研讨会》
会议日期：2014年
学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学]
基 金：partially supported by National Natural Science Foundation of China(No.21172181,21372186) the Research Fund for International Young Scientists from International(Regional)Cooperation and Exchange Program NSFC(No.81450110094) the Specialized Research Fund for the Doctoral Program of Higher Education of China(SRFDP20110182110007)
关 键 词：quinolone imidazole antimicrobial DNA
摘 要：A series of new imidazole quinolone derivatives were synthesized and exhibited significant activities(MIC=0.0039-64μg/mL).The supramolecular interactions of highly active target compound,MRSA DNA and Cuion were investigated and indicated a possible antibacterial action ***,compound forms a binary