Identification of a potent inhibitor of human dual-specific phosphatase,VHR,from computer-aided and NMR-based screening to cellular effects
作者单位：Department of ChemistryAligarh Muslim University
会议名称：《第九届全国酶学学术讨论会暨邹承鲁诞辰85周年纪念会》
会议日期：2008年
学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术]
关 键 词：VHR inhibitors NMR protein tyrosine phosphatases virtual screening
摘 要：Human vaccinia HI-related phosphatase (VHR) is a dual-specific phosphatase (DSPs) that plays an important role in the mitogen activated protein (MAP) kinase cascade *** is also a potential drug target for diseases that are related to