COMBINATION HIGH-DOSE RADIATION THERAPY AND SYSTEMIC CHEMOTHERAPY IMPROVES SURVIVAL IN PATIENTS WITH NEWLY DIAGNOSED METASTATIC NASOPHARYNGEAL CANCER
作者单位：Department of Radiation OncologyNational University Cancer Institute(NCIS)National University Health SystemNational University of SingaporeRepublic of Singapore
会议名称：《第六届全国鼻咽癌学术大会》
会议日期：2010年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：Nasopharyngeal Carcinoma Metastatic Radiation Therapy Outcomes
摘 要：Objectives:To investigate the efficacy of high-dose radiation therapy(RT) to the primary and regional disease in combination with systemic chemotherapy and local treatment to metastatic foci in patients with newly diagnosed metastatic nasopharyngeal carcinoma(NPC).Methods: One hundred and five consecutive patients with pathologically confirmed NPC with distant metastasis at diagnosis seen between 1995 and 2002 were *** were offered cisplatin-based chemotherapy, high-dose radiation therapy(30 Gy) to the head and neck region and active treatment to the metastatic ***:Patients’ median age was 46 years,and all had a Karnofsky Performance Score(KPS) of≥***-nine patients(85%) had metastases confined to one ***-six patients(91%) received at least one cycle of chemotherapy,and 71(68%) received 65 Gy of radiation to the head and neck *** a median follow-up time of 22 months(range 2-142 months),90 patients had deceased,and the median survival time of the entire group was 25 *** 2-and 5-year estimated overall survival (OS) rates were 50%and 17%,*** dose of 65 Gy to the primary region(p=0.05) and number of organs with metastases(single versus multiple)(p=0.002) were independent predictive factors for OS on log-rank *** moderately severe acute toxicities,such as Radiation Therapy Oncology Group(RTOG) grade 3 mucositis,skin desquamation,and leucocytopenia were *** patient experienced Grade 4 acute ***:High dose radiation therapy is indicated for local disease control in patients with metastatic nasopharyngeal carcinoma,and may improve survival when actively used with systemic chemotherapy and local treatment for metastatic *** with single organ metastases have a better prognosis as compared to those with more widespread metastases.