APPLICATION OF SUPERCRITICAL CO2 IN CONTROLLED RELEASE SYSTEM OF ORTHO-HYDROXYBENZOIC ACID WITH POLY(ε-CAPROLACTONE)

作     者：Qun Xu, Zhenzhong Hou, Qi Peng, Maizhi Pang and Jianbo Li College of Materials Engineering, Zhengzhou University, Zhengzhou 450052, P. R. China 

会议名称：《Third East Asian Polymer Conference》

会议日期：2004年

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

摘      要：In recent years, the strategy of using supercritical fluid (SCF) technology for crystal and particle engineering of pharmaceutical materials and drug delivery systems has been showing great promise. Supercritical precipitation or crystallization of drug and incorporation of drugs in a carrier using SCF has also become of interests. And these processes include rapid expansion of supercritical solutions (RESS), the batch and continuous gas anti-solvent (GAS) process and supercritical solution impregnation (SSI), even recently the solution enhanced dispersion by supercritical fluid (SEDS) used by A. M. Juppo, *** this paper, poly (ε-caprolactone) (PCL) was used to prepare a new type of controlled release system, i.e., a model drug ortho-hydroxybenzoic acid was impregnated into the biocompatible and biodegradable polymer