XLF in the repair of replication-dependent DNA double-strand-breaks and senescence

作     者：Dongyun Liu~1,Lin Chen~1,Xiaoli Deng~2,Yusheng Cong~2,Xingzhi Xu~1 1.Laboratory of Cancer Biology,College of Life Sciences,Capital Normal University 2.College of Life Science,Beijing Normal University 

会议名称：《“细胞活动 生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会》

会议日期：2011年

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

关 键 词：XLF HR DSBs Senescence 

摘      要：DNA double-strand-breaks(DSBs) are the most serious DNA damage,which can be repaired mainly by two pathways,namely homologous recombination repair(HR) and non-homologous-end-joining(NHEJ).Failure to repair DSBs can lead to genome instability which is fundamentally important in senescence in all *** (XRCC4-like factor) is a newly identified NHEJ protein,whose loss-of-function mutations result in human immunodeficiency with *** has been reported that XLF facilitates repair of replication-independent DSBs induced by ironing *** this report,we found that depletion of XLF expression by siRNA impaired the repair capacity of DSBs induced by CPT(a topoisomerase I inhibitor), sensitized cells to DNA replication inhibitors,and increased *** also found that XLF is a positive regulator of its *** together,these results indicate that XLF may play a role in the repair of replication-dependent DSBs and senescence.