The obesity-associated FTO regulates gene expression of adipogenic factors
作者单位：Genome Structure & Stability GroupDisease Genomics and Individualized Medicine LaboratoryBeijing Institute of GenomicsChinese Academy of Science
会议名称：《生命的分子机器及其调控网络——2012年全国生物化学与分子生物学学术大会》
会议日期：2012年
学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术]
摘 要：Obesity is the most serious public health problem of the 21st century,with dramatically increasing prevalence in adults and *** discovery of the fat mass and obesity-associated gene(FTO) as the first gene contributing to non-syndromic human obesity by genome-wide association studies has accelerated the research on novel obesity gene(s).We previously showed that FTO as a RNA demethylase oxidatively demethylates the ubiquitous m6A modification in mRNA in vitro and in vivo in a manner comparable to those of the other AlkB family