The role of Nrf2/HO-1 pathway on ischemic postconditioning against acute kidney injury following intestinal ischemia-reperfusion
作者单位：武汉大学人民医院麻醉科 The Medical Departmentthe 3rd Hospital of Wuhan Department of AnesthesiologyRenmin Hospital of Wuhan University Department of thoracic surgeryRenmin Hospital of Wuhan University Department of clinical labRenmin Hospital of Wuhan University Department of AnesthesiologyWashington University School of Medicine Department of AnesthesiologyUnion HospitalTongji Medical CollegeHuazhong University of Science and Technology
会议名称：《中国中西医结合麻醉学会[CSIA]年会暨第二届全国中西医结合麻醉学术研讨会、江苏省中西医结合学会麻醉专业委员会成立大会》
会议日期：2015年
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported by Chinese Natural Science Foundation(NO.81000027 and NO.81400698)
关 键 词：nuclear transcription factor-erythroid 2-related factor 2(Nrf2) heme oxygenase-1 ischemic postconditioning acute kidney injury intestinal ischemia reperfusion
摘 要：This study was designed to confirm the protective effect of intestinal ischemic postconditioning(IPo) protects against intestinal ischemia-reperfusion(ⅡR)-induced acute kidney injury(AKI) and to elucidate the role of Nrf2/HO-l signal pathway in renal *** we show that IPo significantly attenuated IIR-induced AKI,suppressed oxidative stress and systemic inflammatory ***,treating IIR-induced AKI with IPo significantly induced heme oxygenase-1(HO-1) and phosphorylation of nuclear factor-erythroid 2 related factor 2(Nrf2).However,Brusatol,a potent inhibitor of Nrf2,significantly reversed the protective effects of IPo against IIR-induced renal damage and ROS *** experiments revealed that t-BHQ,an activator of Nrf2,could play the similar protective effect as IPo on IIR-induced AKI,suggesting that the IPo protected renal against IIR-induced injury through the Nrf2/HO-1 pathway.