Up-converting NaYF4:0.1%Tm^(3+), 20%Yb^(3+) nanoparticles as luminescent labels for deep-tissue optical imaging
Up-converting NaYF4:0.1%Tm^(3+), 20%Yb^(3+) nanoparticles as luminescent labels for deep-tissue optical imaging作者机构：Wroc?aw Research Centre EIT+ ul. Stab?owicka 147 54-066 Wroc?aw Poland Institute of Immunology and Experimental Therapy Institute of Low Temp & Structure Research
出 版 物：《Journal of Rare Earths》 (稀土学报（英文版）)
年 卷 期：2014年第32卷第3期
页 面：207-212页
核心收录：
学科分类：0709[理学-地质学] 0819[工学-矿业工程] 08[工学] 0708[理学-地球物理学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学]
基 金：Project supported by Wroclaw Research Centre EIT+within the project"The Application of Nanotechnology in Advanced Materials"-NanoMat(POIG.01.01.02-02-002/08)financed by the European Regional Development Fund(Operational Programme Innovative Economy 1.1.2)
主 题：upconverting nanoparticles deep tissue bioimaging lanthanide-doped NPs fluorescent materials rare earths
摘 要：Optical imaging plays an important role in biomedical research being extremely useful for early detection, screening and image-guided therapy. Lanthanide-doped up-converting nanoparticles were ideally suited for bioimaging because they could be ex- cited in near infrared （NIR） and emit in NIR or visible （VIS）. Here, we compared lanthanide doped up-converting NaYF4 and organic fluorophores for application in deep-tissue imaging. For that purpose - tissue phantoms mimicking the natural properties of light scat- tering by living tissues were prepared. The studies allowed to quantitatively compare optical resolution of different fluorescent com- pounds, revealing that the NIR photoexcitation was favorable over conventional UV photoexcitation.
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