Genotypes of Helicobacter pylori in patients with peptic ulcer bleeding

作     者：Chin-LinPerng Hwai-JengLin Wen-ChingLo Guan-YingTseng I-thenSun Yueh-HsingOu 

作者机构：I-LanHospitalDivisionofGastroenterologyDepartmentofHealthTaiwanChina. DivisionofGastroenterologyDepartmentofMedicineVGH-TAIPEITaiwanChina ZhongxiaoMunicipalHospitalTaipeiTaiwanChina Ton-YenGeneralHospitalHsin-ChuTaiwanChina InstituteofBiotechnologyinMedicineSchoolofMedicalTechnologyandEngineeringandSchoolofMedicineNationalYang-MingUniversityTaiwanChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2004年第10卷第4期

页      面：602-605页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This study was supported by VGH 92-230 

主　　题：幽门螺杆菌 基因型 消化道溃疡 消化道出血 并发症 

摘      要：AIM:Helicobacter pyloricauses chronic gastritis, peptic ulcer,gastric cancer and MALT-lymphoma. Different genotypes of Helicobacter pylori are confirmed from diverse geographic areas. Its association with bleeding peptic ulcer remains *** aim of this study was to investigate the Helicobacter pylori vacA alleles, cagA and iceA in patients with bleeding peptic ***:We enrolled patients with bleeding, nonbleeding peptic ulcers and chronic gastritis. Biopsy specimens were obtained from the antrum of the stomach for rapid urease test, bacterial culture and PCR assay. DNA extraction and polymerase chain reaction were used to detect the presence or absence of cagA and to assess the polymorphism of vacA and ***: A total of 168 patients (60.4%) (25 patients with chronic gastritis, 26 patients with bleeding gastric ulcer,51 patients with non-bleeding gastric ulcer, 26 patients with bleeding duodenal ulcer, and 40 patients with non-bleeding duodenal ulcer) were found to have positive PCR results between January 2001 and December 2002. Concerning genotypes, we found cagA (139/278, 50%), vacA s1a(127/278, 45.7%), and iceA1 (125/278, 45%) predominated in all studied patients. In patients with bleeding peptic ulcers,vacA s1a and m1T were fewer than those in patients with non-bleeding peptic ulcers (37/106 vs 69/135, P=0.017, and 4/106 vs 21/135, P=0.002).CONCLUSION:In patients with peptic ulcers, Hpylori vacA s1a and m1T prevent bleeding complication.