L-Arginine/nanofish bone nanocomplex enhances bone regeneration via antioxidant activities and osteoimmunomodulatory properties

作     者：Liping Huang Jianhua Zhang Xianhu Liu Tianbao Zhao Zhipeng Gu Yiwen Li Liping Huang;Jianhua Zhang;Xianhu Liu;Tianbao Zhao;Zhipeng Gu;Yiwen Li

作者机构：School of Materials Science and EngineeringXihua UniversityChengdu 610039China College of Polymer Science and EngineeringState Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Research Institute of Sun Yat-sen University in ShenzhenShenzhen 518057China National Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450002China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第1期

页      面：234-238页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 

基　　金：supported by the Science and Technology Planning Project of Shenzhen(No.JCYJ20180307163534533) the Program of the Science,Technology Department of Guangzhou(No.201803020039) 

主　　题：Antioxidant activities Osteoimmunodulatory properties Bone regeneration Arginine Nanofish bone 

摘      要：In this study,a promising strategy has been developed to promote bone regeneration by combining antioxidant activities and osteoimmunomodulatory ***,an L-arginine/nanofish bone(Arg/NFB) nanocomplex has been prepared and evaluated in vitro and in *** Arg/NFB nanocomplex possesses good antioxidant activities and could modulate the polarization of non-activated macrophage into different types and induce the secretion of pre-inflammato ry,anti-inflammatory,osteogenic as well as angiogenic ***,the regulated immune microenvironment can enhance the osteogenic differentiation of mouse embryo osteoblast precursor cells(MC3 T3-E1) and angiogenic capacity of human umbilical vein endothelial cells(HUVECs),leading to the improved formation of mineralized nodules,alkaline phosphatase activity and angiogenic *** vivo results with cranial defect models reveal that the treatment of Arg/NFB nanocomplex exhibited significant improvement of new bone formation and *** the results demonstrate Arg/NFB nanocomplex with antioxidant activities and osteoimmunomodulatory properties could be a new idea for developing the next generation of bone regeneration biomaterials.