Endothelial surface glycocalyx and vascular mechano-sensing and transduction

作     者：Wanyi Yen Jinlin Yang Min Zeng John M.Tarbell Bingmei M.Fu 

作者机构：Department of Biomedical Engineeringthe City College of the City University of New York 

出 版 物：《医用生物力学》 (Journal of Medical Biomechanics)

年 卷 期：2013年第28卷第S1期

页      面：15-16页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：supported by NIH R01 HL094889-01 

主　　题：transduction hemodynamic activating homeostasis constantly biochemical stimuli regulating stretch lining 

摘      要：Introduction The endothelial cells(ECs)lining every blood vessel wall constantly expose to the mechanical forces generated by the blood *** EC responses to these hemodynamic forces play a critical role in the homeostasis of the circulatory *** addition to forming a transport barrier between the blood and vessel wall,vascular ECs play important roles in regulating circulation *** biochemical stimuli,blood flow induced(hemodynamic)mechanical stimuli,such as shear stress,pressure and circumferential stretch,modulate EC morphology and functions by activating mechanosensors,signaling pathways,and gene and protein *** EC responses to the hemodynamic forces(mechano-sensing and transduction)