Sirtl regulates testosterone biosynthesis in Leydig cells via modulating autophagy

作     者：Muhammad Babar Khawar Chao Liu Fengyi Gao Hui Gao Wenwen Liu Tingting Han Lina Wang Guoping Li Hui Jiang Wei Li Muhammad Babar Khawar;Chao Liu;Fengyi Gao;Hui Gao;Wenwen Liu;Tingting Han;Lina Wang;Guoping Li;Hui Jiang;Wei Li

作者机构：State Key Laboratory of Stem Cell and Reproductive BiologyInstitute of ZoologyChinese Academy of SciencesBejing 100101China School of Biotechnology and FoodShangqiu Normal UniversityShangqiu 476000China University of Chinese Academy of SciencesBeijing 100049China The MOH key Laboratory of GeriatricsBeijing HospitalNational Center of GerontologyBeijing 100730China Department of UrologyPeking University Third HospitalBeijing 100191China Department of AndrologyPeking University Third HospitalBeijing 100191China Department of Reproductive Medicine CenterPeking University Third HospitalBeijing 100191China Department of Human Sperm BankPeking University Third HospitalBeijing 100191China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2021年第12卷第1期

页      面：67-75页

核心收录：

学科分类：0710[理学-生物学] 0905[农学-畜牧学] 09[农学] 090501[农学-动物遗传育种与繁殖] 

基　　金：National Natural Science Foundation of China [2018-I2M-1-002] National Science Fund for Distinguished Young Scholars [91649202, U1904165] 81925015 

主　　题：flow. synthesis primarily 

摘      要：Dear Editor,Steroid hormones are crucial signal molecules that regulate a large number of physiological and developmental *** is the key steroid hormone required for the development of male characteristics and also supports the physiology of the male reproductive system(Sinclair et al.,2015).Testosterone is primarily produced by the Leydig cells residing in the testicular *** cholesterol acts as a substrate for the biosynthesis of *** steroidogenic cells are capable of stor-ing only very ltte hormone,rapid synthesis of hormone requires the mobilization of the precursor cholesterol,chiefly stored as intracellular lipid droplets(LDs)(Danielsen et al.,2016).Leydig cells are the major sites to produce testos-terone,there are extremely active autophagy in them,and a decline in steroidogenesis has also been associated with the decline of autophagic ***,the disruption of autophagy leads to decreased intracellular LDs,and there-fore affects testosterone synthesis in the Leydig cells(Danielsen et al..2016;Gao et al,2018).