Mitochondrion targeting peptide-modified magnetic graphene oxide delivering mitoxantrone for impairment of tumor mitochondrial functions

作     者：Hangqi Zhu Bing Zhang Nali Zhu Mingchun Li Qilin Yu Hangqi Zhu;Bing Zhang;Nali Zhu;Mingchun Li;Qilin Yu

作者机构：Key Laboratory of Molecular Microbiology and TechnologyMinistry of EducationDepartment of MicrobiologyCollege of Life SciencesNankai UniversityTianjin 300071China College of ChemistryState Key Laboratory of Elemento-Organic ChemistryNankai UniversityTianjin 300071China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin 300072China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第3期

页      面：1220-1223页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 10[医学] 

基　　金：supported by National Natural Science Foundation of China(No.31870139) Natural Science Foundation of Tianjin(No.19JCZDJC33800) Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(No.TSBICIP-KJGG-006) the Fundamental Research for the Central Universities 

主　　题：Magnetic graphene oxide Nanocarrier Mitochondrion-targeting peptide Mitoxantrone Cancer therapy 

摘      要：In this study,we prepared mitochondrion targeting peptide-grafted magnetic graphene oxide(GO)nanocarriers for efficient impairment of the tumor *** two-dimensional GOMNP-MitP nanosheets were synthesized by grafting magnetic y-Fe_(2)O_(3)to the surface of GO,followed by covalent modification of mitochondrion targeting peptide(MitP).GOMNP-MitP exhibited the high capacity of loading the anticancer drug mitoxantrone(MTX),and preferentially targeted the tumor *** the aid of alternating magnetic field(AMF),the MTX-loading GOMNP-MitP released MTX to the mitochondria,severely impairing mitochondrial functions,including attenuation of ATP production,decrease in mitochondrial membrane potential(MMP),and further leading to activation of *** study realized high-efficient mitochondrion-ta rgeting drug delivery for anticancer therapy by twodimensional nanoplatforms.