Recent advances in fluorescence imaging of alkaline phosphatase

作     者：Meng Li Bhaskar Gurram Shan Lei Nicholas TBlum Peng Huang Jing Lin Meng Li;Bhaskar Gurram;Shan Lei;Nicholas T.Blum;Peng Huang;Jing Lin

作者机构：Marshall Laboratory of Biomedical Engineering.International Cancer CenterLaboratory of Evolutionary Theranostics(LET)School of Biomedical Engineering.Shenzhen University Health Science CenterShenzhen 518060China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第4期

页      面：1316-1330页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 

基　　金：supported by National Key Research and Development Program(No.2018YFA0704003) Basic Research Program of Shenzhen(Nos.JCYJ20170412111100742,JCYJ20180507182413022) Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China(No.161032) Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project(No.2018B030308003) 

主　　题：Alkaline phosphatase Acid phosphatase Fluorescence imaging Luminescence mechanism 

摘      要：Phosphatase plays a vital important role in many biological functions due to the dephosphorylation serves varied roles in cellular regulation and *** the family of phosphatase,alkaline phosphatase(ALP)could act as crucial prognostic indicators for many diseases such as bone diseases and ***,the detection of ALP is mainly limited to in vitro colorimetric method in ***,huge efforts have been paid on the fluorescence imaging that provides a reliable method to detect the real-time and in vivo changes of the level of *** this review,we summarize recent advances in fluorescence imaging of phosphatase,mainly focused on *** imaging probes of phosphatase are mainly classified according to their luminescence *** the end,we assessed the challenges and future prospects of phosphatase probes.