Assessment of the forensic application of 50 Y-STR markers in a large pedigree
作者机构：West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengduChina Criminal Technology DepartmentLiupanshui Public Security BureauGuizhouChina
出 版 物：《Forensic Sciences Research》 (法庭科学研究（英文）)
年 卷 期：2022年第7卷第2期
页 面：207-210页
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 08[工学] 0838[工学-公安技术] 100105[医学-法医学] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China[grant number 81401557] This study was funded by ICH-GCP Standardization Construction and Innovation of GCP System[grant number 2018ZX09201018-020]
主 题：Forensic sciences forensic genetics Y-STR haplotype rapid mutation pedigree
摘 要：Short tandem repeats on the Y chromosome(Y-STRs),characterized by paternal inheritance,are valuable in forensic ***,the potential application of Y-STRs in pedigrees should be drawn upon,especially in China’s surname-concentrated natural *** study focused on 50 Y-STRs,including 13 rapidly mutating(RM)Y-STRs that largely constitute the current Y-STR commercial kits,and determined the differences in these Y-STRs between branches in a large pedigree and the discriminatory power of these haplotypes in different units for male *** indicated in the results,14 inconsistencies were observed at 9 Y-STRs between 10 father-son *** addition,these 50 Y-STR haplotypes discriminated 10 out of 47 father-son pairs,106 of 148 cousin pairs,70 of 119 uncle-nephew pairs,17 of 39 brother pairs,and 14 out of 33 grandfather-grandson pairs in a large *** RM Y-STR set is able to differentiate close male relatives in a large pedigree.
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