Radiolabeling of lacosamide using highly purified rhenium-188 as a prospective brain theranostic agent

作     者：H.A.El-Sabagh M.I.Aydia A.M.Amin K.M.El-Azony H. A. El-Sabagh;M. I. Aydia;A. M. Amin;K. M. El-Azony

作者机构：Labeled Compound DepartmentRadioisotopes Production DivisionHot Laboratory CenterAtomic Energy AuthorityP.O.Box 13759 CairoEgypt Radioactive Isotopes and Generators DepartmentRadioisotopes Production DivisionHot Laboratory CenterAtomic Energy AuthorityP.O.Box 13759 CairoEgypt 

出 版 物：《Nuclear Science and Techniques》 (核技术（英文）)

年 卷 期：2020年第31卷第10期

页      面：105-114页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

主　　题：Lacosamide 188Re 188W/188Re generator Radiolabeling 

摘      要：Rhenium-188 is prospectively effective for both diagnosis and radiotherapy as it appropriately emits gamma rays and beta ***(LCM)is a newly approved antiepileptic medication for focal drug-resistant ***-188 was separated with high elution yield and high purity using the new 188W/188Re generator based on the ZrSiW gel matrix.188Re-LCM was prepared with high radiochemical yield and high *** of 188Re-LCM in normal Swiss albino mice was investigated to determine its utility as a potential brain therapy *** 188W/188Re generator was used to obtain 188Re based on the ZrSi188W gel matrix,and the chemical,radiochemical,and radionuclidic purity of the obtained 188Re was determined using inductively coupled plasma optical emission spectrometry(ICP-AES),a paper chromatography technique,and high-purity germanium(HPGe)detection,respectively,to assess its validity for LCM *** factors,such as the pH,reaction time,and LCM quantity,were therefore studied in order to improve the yield and purity of 188Re-LCM,as determined by various chromatographic techniques such as electrophoresis,thin layer chromatography(TLC),and highpressure liquid chromatography(HPLC).188Re was obtained with a high elution yield(75±3%)and a low 188W breakthrough(0.001±0.0001%).The maximum radiochemical yield of 188Re-LCM(87.5±1.8%)was obtained using 50 ll LCM(4 mM),250 ll stannous chloride(4.4 mM)at pH 4,100 ll 188Re(37 MBq),within 30 min,at room temperature(25±3C),as determined by TLC,electrophoresis,and HPLC *** analysis showed that 188Re-LCM was primarily localized in the brain(5.1%)with a long residence time(240 min).