Biodegradable Zn–3Cu and Zn–3Cu–0.2Ti alloys with ultrahigh ductility and antibacterial ability for orthopedic applications

作     者：Jixing Lin Xian Tong Kun Wang Zimu Shi Yuncang Li Matthew Dargusch Cuie Wen Jixing Lin;Xian Tong;Kun Wang;Zimu Shi;Yuncang Li;Matthew Dargusch;Cuie Wen

作者机构：Department of Material EngineeringZhejiang Industry&Trade Vocational CollegeWenzhou325003China School of Materials Science and EngineeringXiangtan UniversityXiangtan411105China Key Laboratory of Materials PhysicsInstitute of Solid State PhysicsChinese Academy of SciencesHefei230031China School of EngineeringRMIT UniversityMelbourneVictoria3001Australia Centre for Advanced Materials Processing and Manufacturing(AMPAM)The University of QueenslandBrisbaneQueensland.4072Australia 

出 版 物：《Journal of Materials Science & Technology》 (材料科学技术（英文版）)

年 卷 期：2021年第68卷第9期

页      面：76-90页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：supported financially by the Research Funds of the Wenzhou Science and Technology Bureau (Nos.ZG2019022 and 2018ZG008) support for this research by the Australian Research Council (ARC) through the Discovery Project (No.DP170102557) the Future Fellowship(No.FT160100252) support of the ARC Research Hub for Advanced Manufacturing of Medical Devices (No.IH150100024) 

主　　题：Cytotoxicity Degradation behavior Mechanical properties Zn-Cu biodegradable metals 

摘      要：Zinc(Zn) and its alloys have been proposed as biodegradable implant materials due to their unique combination of biodegradability, biocompatibility, and biofunctionality. However, the insufficient mechanical properties of pure Zn greatly limit its clinical application. Here, we report on the microstructure, mechanical properties, friction and wear behavior, corrosion and degradation properties, hemocompatibility, and cytocompatibility of Zn–3 Cu and Zn–3 Cu–0.2 Ti alloys under three different conditions of as-cast(AC),hot-rolling(HR), and hot-rolling plus cold-rolling(HR + CR). The HR + CR Zn–3 Cu–0.2 Ti exhibited the best set of comprehensive properties among all the alloy samples, with yield strength of 211.0 MPa, ultimate strength of 271.1 MPa, and elongation of 72.1 %. Immersion tests of the Zn–3 Cu and Zn–3 Cu–0.2 Ti alloys in Hanks’ solution for 3 months indicated that the AC samples showed the lowest degradation rate,followed by the HR samples, and then the HR + CR samples, while the HR + CR Zn–3 Cu exhibited the highest degradation rate of 23.9 m/a. Friction and wear testing of the Zn–3 Cu and Zn–3 Cu–0.2 Ti alloys in Hanks’ solution indicated that the AC samples showed the highest wear resistance, followed by the HR samples, and then the HR + CR samples, while the AC Zn–3 Cu–0.2 Ti showed the highest wear *** diluted extracts of HR + CR Zn–3 Cu and Zn–3 Cu–0.2 Ti at a concentration of ≤25 % exhibited noncytotoxicity. Furthermore, both the HR + CR Zn–3 Cu and Zn–3 Cu–0.2 Ti exhibited effective antibacterial properties against S. aureus.