Prolonged prothrombin time at admission predicts poor clinical outcome in COVID-19 patients

作     者：Lang Wang Wen-Bo He Xiao-Mei Yu Da-Long Hu Hong Jiang 

作者机构：Department of CardiologyRenmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Cardiovascular Research InstituteWuhan UniversityWuhan 430060Hubei ProvinceChina Hubei Key Laboratory of CardiologyWuhan 430060Hubei ProvinceChina School of Biotechnology and Biomolecular SciencesThe University of New South WalesSydney 2052Australia 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2020年第8卷第19期

页      面：4370-4379页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the National Natural Science Foundation of China No.81570450 and No.81900455 

主　　题：COVID-19 Coagulation Prothrombin time Fibrin degradation products Prognosis Infectious disease 

摘      要：BACKGROUND Supported by the National Natural Science Foundation of China,*** prognostic value of coagulation disorder in coronavirus disease 2019(COVID-19)patients should be *** To investigate the abnormalities of coagulation parameters in the patients with COVID-19 and their prognostic *** Consecutive patients admitted in the isolation ward of Renmin Hospital of Wuhan University from January 31 to February 5,2020 with confirmed COVID-19 were *** primary outcomes were death and survival as of March ***,vital signs,comorbidities and laboratory tests were collected and compared between those who died and *** regression analysis for prognostic factors was ***-Meier analysis was used to compare the estimated survival rate between patients with prolonged prothrombin time and normal prothrombin *** The total number of patients with confirmed COVID-19 who were enrolled was *** median age was 62 years,and 95 patients(44.6%)were ***-one patients were critical(23.9%),79 patients were severe(37.1%)and 83 patients were moderate(39%).As of March 11,2020,99 patients were discharged(46.5%),79 patients(37.1%)stayed in the hospital and 35 patients(16.2%)*** time to death was 6(4-8)d,while median hospital stay was 32(22-36)d in survivors(P0.001).More men(P=0.002)and elderly patients(P0.001)were found in the group of those who *** respiration rate at admission was higher in the group of those who died(P0.001).The incidences of hypertension(P=0.028),cerebrovascular disease(P0.001),chronic kidney disease(P=0.02)and chronic obstructive pulmonary disease(P0.001)were higher in the group of those who *** count was decreased in the group of those who died(P=0.002)whereas prothrombin time(P0.001),activated partial thromboplastin time(P=0.033),concentration of D-dimer(P0.001)and fibrin degradation products(P0.001)were increased in the group of those who ***