Ultra-stable and multistimuli-responsive nanoparticles coated with zwitterionic pillar[n]arene for enhanced cellular uptake

作     者：Yupeng Jiao Shang Lan Da Ma Yupeng Jiao;Shang Lan;Da Ma

作者机构：Department of ChemistryFudan UniversityShanghai 200433China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第3期

页      面：1025-1028页

核心收录：

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0702[理学-物理学] 

基　　金：National Natural Science Foundation of China(Nos.21672042 and 21921003)for financial support 

主　　题：Host-guest systems Stimuli responsiveness Zwitterionic ligands Gold nanoparticles Cellular uptake 

摘      要：Nanoparticle surface property is crucial for circulation stability,cellullar uptake and other biological *** rionic pillar[n]arenes(ZPns)we re used to coat gold nanopa rticles(GNPs)via hostguest *** resulting GNPs demonstrated higher stability in blood serum compared to polyethylene glycol(PEG)-coated ***-coated GNPs were responsive to UV-irradiation,competitive displacement and acidic ***-irradiation or competitive displacement could lead to the removal of ZPn coating to expose GNPs,which enhanced cell uptake efficiency by 5.9-and 7.4-fold,respectively.