Age-related modifications of macrophages influenced by “inflammageing”in graft vs. host disease
作者机构：Fujian Institute of HematologyFujian Provincial Key Laboratory on HematologyDepartment of HematologyFujian Medical University Union HospitalFuzhou350000China Union Clinical Medical CollegesFujian Medical UniversityFuzhou350000China Faculty of Life Sciences and MedicineKing’s College LondonLondonUK INSERM U1160Hopital Saint LouisUniversitéParis DiderotSorbonne Paris CitéParisFrance
出 版 物：《BIOCELL》 (生物细胞（英文）)
年 卷 期：2020年第44卷第2期
页 面：237-246页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：the topnotch innovative talents project and the project of Fujian Science and Technology Department(Grant 2016Y9025&2016J06018&2017I0004) Fujian Medical University teaching reform project(Y17005) Fujian Provincial Health and Family planning Commission Youth Research Project(2017-1-6)to LI.URL:http://kjt.fujian.gov.cn/
主 题：Macrophages Inflamm-ageing Graft vs host disease Hematopoietic stem cell transplantation Age Innate immune cells
摘 要：Most studies focus on the adaptive immune cells in the GVHD pathogenesis,while little is known about innate immune cells in GVHD occurrence and development,especially ***,a higher incidence of graft versus host disease(GVHD)is also found in the elderly *** advances have been made in the modification of macrophages influenced by the inflamm-ageing,there is still no review on the role of macrophages in GVHD and the association between GVHD and the altered macrophages by *** this review,we focus on the potential age-related modifications of macrophage in GVHD,which contributes to the change of morbidity and mortality of *** literature review,we found that the infiltration of macrophages is associated with GVHD and macrophages are modified in inflamm-ageing state,including the proliferation,migration,phagocytosis,antigen presentation,interaction with other immune cells,and *** suppose that altered macrophage functions in inflamm-ageing state contribute to GVHD in elderly patients.
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