Pore characterization of PM Mg–0.6Ca alloy and its degradation behavior under physiological conditions

作     者：Eshwara Phani Shubhakar Nidadavolu Diana Krüger Berit Zeller-Plumhoff Domonkos Tolnai Björn Wiese Frank Feyerabend Thomas Ebel Regine Willumeit-Römer 

作者机构：Division Metallic BiomaterialsInstitute of Materials ResearchHelmholtz-Zentrum GeesthachtMax-Planck-Str.1Geesthacht 21502Germany Magnesium Innovation Center(MagIC)Institute of Materials ResearchHelmholtz-Zentrum GeesthachtMax-Planck-Str.1Geesthacht 21502Germany 

出 版 物：《Journal of Magnesium and Alloys》 (镁合金学报（英文）)

年 卷 期：2021年第9卷第2期

页      面：686-703页

核心收录：

学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：funding from the Helmholtz Virtual Institute“In vivo studies of biodegradable magnesium based implant materials(Met Bio Mat)”under grant agreement no.VH-VI-523 

主　　题：Porous Mg-0.6Ca In vitro Degradation μCT Sintering 

摘      要：Several material parameters affect degradation characteristics of Mg and its alloys under physiological *** Mg materials are interesting for their simultaneous degradation and drug delivery ***,an increase in pore surface area is detrimental to both degradation resistance and subsequent mechanical *** present work aims at determining the threshold porosity value in Mg–0.6 Ca specimens produced by powder metallurgy(PM)below which low degradation rates persist with acceptable mechanical *** different porous Mg–0.6 Ca specimens containing both closed and open pore structures were fabricated with porosities ranging from 3%to 21%.Degradation profiles were obtained via a semi static immersion test over 16 days under physiological conditions using Dulbecco’s modified Eagle’s medium with Glutamax and 10%fetal bovine serum as *** results are related to morphological pore parameters like pore size distribution,pore interconnectivity and pore curvatures that were quantified using an ex situμCT *** general,with decreasing porosity a decrease in pore interconnectivity is seen followed by rounding of the *** degradation rates(MDR0.3 mm/year)are observed in specimens until 10%porosity,however,the upper bound for reproducible degradation is observed to be in specimens until 12%*** porosity level also marks the transition from closed to open pore nature with a simultaneous change in pore interconnectivity from less than 10%to greater than 95%,below and above this porosity level,*** tensile strength and elongation to failure recorded for specimens with 10%porosity were 70 MPa and 2%,respectively displaying positive traits of both homogenous degradation and mechanical *** results suggest that high pore interconnectivity is the dominant factor controlling degradation and mechanical properties in porous Mg-0.6 Ca *** results also indicate a good sintering respons