Primary liver transplantation vs liver resection followed by transplantation for transplantable hepatocellular carcinoma:Liver functional quality and tumor characteristics matter

作     者：Mehmet Fatih Can Christopher B Hughes 

作者机构：Division of Gastrointestinal SurgeryDepartment of SurgeryGulhane School of MedicineEtlik 06018Ankara AnkaraTurkey Thomas Starzl Transplantation InstituteUniversity of Pittsburgh Medical CenterPittsburghPA 15213United States 

出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志（英文版）（电子版）)

年 卷 期：2013年第5卷第1期

页      面：5-8页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Hepatocellular carcinoma Chronic liver disease Liver transplantation Liver resection Salvage transplantation Survival 

摘      要：Liver resection(LR) and primary liver transplantation(LT) are two potentially curative treatment modalities for patients with hepatocellular carcinoma(HCC).If an underlying chronic liver disease exists,however,making a decision on which method should be selected is *** a patient has no chronic liver disease,LR may be the preferable option with salvage transplantation(ST) in mind in case of *** of a moderate-to-severe liver failure accompanying HCC usually warrants primary *** treatment of patients with HCC and early-stage chronic liver disease remains *** advantages of LR-followed-by-STif-needed strategy include less complicated index operation,no need for immunosuppression,use of donor livers for other patients in today s organ shortage setting and comparable survival ***,primary LT has its own advantages as it also treats underlying chronic liver disease with carcinogenic potential,removes undetected tumor nodules and potentially eliminates need for a *** article recently published by Fuks et al in Hepatology offers an approach by which selecting between LR-followed-by-ST and immediate LT might be *** we discuss the results of the aforementioned report in the light of currently available knowledge.