Delirium,insulin-like growth factor I,growth hormone in older inpatients
作者机构：Department of PsychiatrySligo/Leitrim Mental Health ServicesSligo F91 CD34Ireland Department of PsychiatryResearch and Academic Institute of AthensAthens 11742Greece Department of PsychiatryUniversity Hospital LimerickLimerick V94 F858Ireland Department of PsychiatryGGZinGeest and VuMCAmsterdam 1081 HVthe Netherlands Department of Psychiatry and Center for Geriatric and GerontologyKaohsiung Veterans General HospitalKaohsiung 81362Taiwan Department of Biopharmaceutical and Medical ScienceSchool of Science and ComputingGalway-Mayo Institute of TechnologyGalway H91 T8NWIreland Department of PathologySligo University HospitalSligo F91 H684Ireland
出 版 物：《World Journal of Psychiatry》 (世界精神病学杂志)
年 卷 期：2020年第10卷第9期
页 面：212-222页
核心收录：
学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学]
基 金：Research and Education Foundation Sligo University Hospital Sligo Ireland
主 题：Delirium Pathophysiology Insulin-like growth factor-I Growth hormone Older people Physical illness Cognition Old age psychiatry
摘 要：BACKGROUND Delirium is a common disorder in elderly medical inpatients with serious adverse outcomes and is characterized by sudden onset,disturbance in attention,awareness,consciousness and cognition,and often with behavioural *** to understanding delirium,is understanding mechanisms by which body and brain wellbeing are linked and in particular how brain responses to bodily homeostatic stress is mediated.A number of studies have investigated the relationship between insulin-like growth factor I(IGF-I)and delirium in medically ill hospitalised patients with conflicting ***,none have investigated growth hormone(GH)which is related to IGF-I via negative *** To investigate the relationship between serum levels of IGF-I and GH,and the occurrence of *** Prospective,longitudinal,observational *** elderly inpatients(aged 70+),were assessed twice weekly with Montreal cognitive assessment(MoCA),Confusion assessment method(CAM),Acute Physiology and Chronic Health Evaluation *** was defined using *** history of dementia was evaluated with the Informant Questionnaire on Cognitive Decline in the ***-I and GH levels were estimated with the ELISA *** estimating equations(GEE)model was applied for the first five assessments to analyze those longitudinal *** The sample consisted of 198 participants(mean age 80.63±6.81;range 70-97).Of these 92(46.5%)were *** six(43.4%)were identified with a history of *** or prevalent delirium during hospitalisation was identified with CAM in 40 participants(20.2%).Evaluation of missing values with Little s MCAR test indicated that they were missing completely at random(MCARχ2=12.24,u:9,P=0.20).Using GEE for the analysis we found that low MoCA scores,low levels of IGF-I and high levels of GH were significantly associated with any delirium(prevalence,incident,or fluctuating,during the study period(Waldχ2=12.231;u:
维普期刊数据库