MiR-135a biogenesis and regulation in malignancy:a new hope for cancer research and therapy

作     者：Zhe Cao Jiangdong Qiu Gang Yang Yueze Liu Wenhao Luo Lei You Lianfang Zheng Taiping Zhang Zhe Cao;Jiangdong Qiu;Gang Yang;Yueze Liu;Wenhao Luo;Lei You;Lianfang Zheng;Taiping Zhang

作者机构：Department of General SurgeryPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Nuclear MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Clinical Immunology CenterChinese Academy of Medical SciencesBeijing 100730China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2020年第17卷第3期

页      面：569-582页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by grants from the National Natural Science Foundation of China(Grant Nos.81772639,81802475,81972258,and 81974376) the Natural Science Foundation of Beijing(Grant No.7192157) CAMS Innovation Fund for Medical Sciences(CIFMS)(Grant No.2016-I2M-1-001) China Postdoctoral Science Foundation(Grant No.198831) and the National Key R&D Program of China(Grant No.2018YFE0118600) 

主　　题：Biomarker cancer chemoresistance epithelial-mesenchymal transition miR-135a therapeutics 

摘      要：MicroRNAs(miRNAs)are evolutionarily conserved small non-coding RNAs that affect posttranscriptional regulation by binding to the 3′-untranslated region of target messenger ***-135a is a critical miRNA that regulates gene expression,and many studies have focused on its function in cancer ***-135a is dysregulated in various cancers and regulates cancer cell proliferation and invasionvia several signaling pathways,such as the MAPK and JAK2/STAT3 ***-135a has also been found to promote or inhibit the epithelial-mesenchymal transition and chemoresistance in different *** studies have discovered the value of miR-135a as a novel biomarker for cancer diagnosis and *** studies have suggested the potential of therapeutically manipulating miR-135a to improve the outcome of cancer *** these findings have demonstrated the role of miR-135a in cancer progression and clinical applications,a number of questions remain to be answered,such as the dual functional roles of miR-135a in *** this review,we summarize the available studies regarding miR-135a and cancer,including background on the biogenesis and expression of miR-135a in cancer and relevant signaling pathways involved in miR-135a-mediated tumor *** also focus on the clinical application of miR-135a as a biomarker in diagnosis and as a therapeutic agent or target in cancer treatment,which will provide a greater level of insight into the translational value of miR-135a.