A genome-wide screening for DNA repair genes:much more players than hitherto known

作     者：Bernd Kaina Bernd Kaina

作者机构：Institute of ToxicologyUniversity Medical CenterObere Zahlbacher Str.67MainzGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2020年第5卷第1期

页      面：806-807页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：Open access funding provided by Projekt DEAL 

主　　题：networks damage removing 

摘      要：Since the discovery of the structure of DNA and the statement by Francis Crick that DNA is“…so precious that probably many distinct repair mechanisms would exist,1 a plethora of DNA alterations induced by exogenous and endogenous genotoxins has been identified,together with complex cellular processes that sense the damage,remove it from the macromolecule or tolerate it during ***-driven pathways signal downstream to complex networks,which regulate the balance between survival and death,and are collectively referred to as the DNA damage response(DDR).The classical DNA repair and DDR pathways have been elucidated in detail and a tight entanglement has been uncovered between ATM-ATR-DNA-PK driven pathways,chromatin remodeling,damage recruiting factors,and mechanisms removing or tolerating DNA damage in a simple(damage reversal)or more complex way(Fig.1).