视盘地形图的基线测量与原发性开角型青光眼的发生相关:共焦扫描激光眼底镜辅助行高眼压治疗的研究
Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma: The Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study作者机构：HamiltonGlaucomaCenter and Diagnostic Imaging Laboratory Department of Ophthalmology University of California San Diego San Diego CA 92093-0946 United States Dr
出 版 物：《世界核心医学期刊文摘(眼科学分册)》 (Digest of the World Core Medical Journals)
年 卷 期：2006年第1期
页 面：24-25页
学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学]
主 题：原发性开角型青光眼 眼底镜 高眼压 视盘 共焦扫描 基线测量 地形图 激光
摘 要：Objective: To determine whether baseline confocal scanning laser ophthalmoscopy (CSLO) optic disc topographic measurements are associated with the development of primary open-angle glaucoma (POAG) in individuals with ocular hypertension. Methods: Eight hundred sixty-five eyes from 438 participants in the CSLO Ancillary Study to the Ocular Hypertension Treatment Study with good-quality baseline CSLO images were included in this study. Each baseline CSLO parameter was assessed in univariate andmultivariate proportional hazards models to determine its association with the development of POAG. Results: Forty-one eyes from 36 CSLO Ancillary Study participants developed POAG. Several baseline topographic optic disc measurements were significantly associated with the development of POAG in both univariate and multivariate analyses, including larger cup-disc area ratio,mean cup depth, mean height contour, cup volume, reference plane height, and smaller rim area, rim area to disc area, and rim volume. In addition, classification as “ outside normal limits by the Heidelberg Retina Tomograph classification and the Moorfields Regression Analysis classifications (overall, global, temporal inferior, nasal inferior, and superior temporal regions) was significantly associated with the development of POAG. Within the follow-up period of this analysis, the positive predictive value of CSLO indexes ranged from 14% (Heidelberg Retina Tomograph classification and Moorfields Regression Analysis overall classification) to 40% for Moorfields Regression Analysis temporal superior classification. Conclusions: Several baseline topographic optic disc measurements alone or when combined with baseline clinical and demographic factors were significantly associated with the development of POAG among Ocular Hypertension Treatment Study participants. Longer follow-up is required to evaluate the true predictive accuracy of CSLO measures.
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