Rho A/Rho kinase in spinal cord injury

作     者：Xiangbing Wu Xiao-ming Xu 

作者机构：Spinal Cord and Brain Injury Research Group Stark Neurosciences Research Institute Indiana University School of Medicine Department of Neurological Surgery Indiana University School of Medicine Goodman Campbell Brain and Spine Indiana University School of Medicine Department of Anatomy & Cell Biology Indiana University School of Medicine 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2016年第11卷第1期

页      面：23-27页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by NIH NS050243,NS059622,NS073636,DOD CDMRP W81XWH-12-1-0562,DVA 1I01BX002356-01A1 Craig H Neilsen Foundation#296749 Wallace H.Coulter Foundation Indiana Spinal Cord and Brain Injury Research Foundation Mari Hulman George Endowment Funds 

主　　题：Rho A Rho kinase inflammation cell death degeneration regeneration spinal cord injury 

摘      要：A spinal cord injury refers to an injury to the spinal cord that is caused by a trauma instead of diseases. Spinal cord injury includes a primary mechanical injury and a much more complex secondary injury process involving inflammation, oxidation, excitotoxicity, and cell death. During the secondary injury, many signal pathways are activated and play important roles in mediating the pathogenesis of spinal cord injury. Among them, the Rho A/Rho kinase pathway plays a particular role in mediating spinal degeneration and regeneration. In this review, we will discuss the role and mechanism of Rho A/Rho kinase-mediated spinal cord pathogenesis, as well as the potential of targeting Rho A/Rho kinase as a strategy for promoting both neuroprotection and axonal regeneration.