A Potential Role for CXCR2 in Early-onset Preeclampsia:Placental CXCR2 Expression is Related to Increased Blood Pressure and Serum LDH Levels

作     者：Zhang Yan-Ping Liu Xi-Jing Jia Jin Wang Tao Li Li Zhou Rong Zhang Yan-Ping;Liu Xi-Jing;Jia Jin;Wang Tao;Li Li;Zhou Rong

作者机构：Department of Obstetrics and GynecologyWest China Second University HospitalSichuan UniversityKey Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)of Ministry of EducationSichuan 610041China Laboratory of Molecular Translational MedicineCenter for Translational MedicineKey Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)of Ministry of EducationWest China Second University HospitalSichuan UniversitySichuan 610041China Department of Obstetrics and GynecologyArmy Medical center of PLAThird Military Medical UniversityChongqing 400038China 

出 版 物：《Maternal-Fetal Medicine》 (母胎医学杂志（英文）)

年 卷 期：2020年第2卷第3期

页      面：148-153页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：This work was supported by the National Natural Science Foundation of China(No.81571465 No.81871175) 

主　　题：Pre-eclampsia CXCR2 Placenta Systolic blood pressure LDH 

摘      要：Objective:This study was aimed to determine the changes in CXCR2 expression in preeclampsia placenta and its correlation with clinical ***:Sixty-four gravidas ranging in age from 25 to 42 years referred to the obstetrics unit of the West China Second University Hospital from April 2012 to October 2012 were recruited in this case-control study;women were diagnosed and divided into early-onset preeclampsia group(n=22),late-onset preeclampsia group(n=22),and healthy pregnancy group(n=20).After immunolocalized in human placenta,the levels of CXCR2 protein and messenger ribonucleic acid(mRNA)were detected by enzyme-linked immunosorbent assay and real-time quantitative polymerase chain *** between placental CXCR2 protein expression with systolic blood pressure and lactate dehydrogenase(LDH)in early-onset preeclampsia were examined using Pearson or Spearman’s correlation ***:Placental CXCR2 protein and mRNA expression in early-onset preeclampsia was significantly lower than it was in placentas from healthy pregnancy pregnancies and late-onset preeclampsia(P0.05).The placental CXCR2 protein expression correlated negatively with systolic blood pressure and LDH in early-onset preeclampsia(r=-0.51,P0.05;r=-0.43,P0.05).Conclusion:Significant abnormal placental CXCR2 expression in early-onset preeclampsia,and its correlations with some clinical parameters(systolic blood pressure and LDH)were discovered,suggesting that CXCR2 may play a role in the pathogenesis of early-onset preeclampsia.