Aldehyde-Sodium Alginate and Amino-Gelatin Preparation as Soft Tissue Adhesive

作     者：袁柳 耿晓华 李家俊 孙彬彬 莫秀梅 

作者机构：State Key Laboratory for Modification of Chemical Fibers and Polymer MaterialsCollege of Materials Science and EngineeringDonghua University Biomaterials and Tissue Engineering LaboratoryCollege of ChemistryChemical Engineering and BiotechnologyDonghua University 

出 版 物：《Journal of Donghua University(English Edition)》 (东华大学学报（英文版）)

年 卷 期：2014年第31卷第4期

页      面：503-506页

核心收录：

学科分类：07[理学] 08[工学] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 

基　　金：National Natural Science Foundations of China(Nos.30973105,31271035) Shanghai Committee of Science and Technology of Nano Special,China(No.11nm0506200) Ph.D.Programs Foundation of Ministry of Education of China(No.20130075110005) 

主　　题：oxidized sodium alginate amino-gelatin adhesive agent 

摘      要：Sodium alginate and gelatin are both remarkable natural biomaterials; they all have been extensively applied in tissue engineering and other relative fields,due to their low price and good biocompatibility. In this paper,we oxidized sodium alginate with sodium periodate to convert 1,2-hydroxyl groups into aldehyde groups to get aldehyde-sodium alginate( A-SA). Gelatin was modified with ethylenediamine( ED) in the presence of water-soluble1-ethyl-3( 3-dimethylaminopropyl) carbodiimide( EDC) to introduce additional amino groups to get amino-gelatin. Upon mixing the A-SA and amino-gelatin aqueous solutions together,a gel rapidly formed based on the Schiff s base reaction between the aldehyde groups in A-SA and the amino groups in *** transform infrared spectroscopy( FTIR) analysis confirmed the characteristic peak of Schiff s base group in the hydrogel. The gelation time measure has confirmed the gelation time is dependent on the aldehyde group content in A-SA and amino group content in amino-gelatin. The fasted hydrogel formation takes place within 30 s. The entire test suggested that this gel could be a promising candidate as soft tissue adhesive.