Increased plasma C-reactive protein level predicts rapid progression of non-target atherosclerotic lesions in patients with stable angina after stenting
Increased plasma C-reactive protein level predicts rapid progression of non-target atherosclerotic lesions in patients with stable angina after stenting作者机构：Department of Cardiology Fu Wai Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100037 China
出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)
年 卷 期：2011年第124卷第19期
页 面：3022-3029页
核心收录：
学科分类：0710[理学-生物学] 12[管理学] 071010[理学-生物化学与分子生物学] 1201[管理学-管理科学与工程(可授管理学、工学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术]
基 金：This study was partly supported by grants for PhD. candidate from Fu Wai Hospital (No. 2004190) National Natural Science Foundation of China (No. 30670861 No. 30871055 and No. 81070171) Beijing Natural Science Foundation (No. 7082081) and Specialized Research Fund for the Doctoral Program of High Education of China (No. 20070023047)
主 题：C-reactive protein inflammation angina pectoris angiography stents
摘 要：Background Although the role of C-reactive protein （CRP） in predicting rapid progression of atherosclerotic lesions has been intensively studied in unstable coronary artery disease, the data from patients with stable angina （SA） are largely absent. The present study evaluated a middle-size patient cohort who underwent percutaneous coronary intervention （PCI） with stent implantation and follow-up coronary angiography （CAG） and tested the hypothesis that increased plasma level of high-sensitive CRP would indicate rapid progression of de novo non-target coronary artery lesions in Chinese patients with *** The study population comprised of 311 consecutive patients with chronic SA who underwent coronary stent implantation on initial admission and angiographic follow-up （（8.5±1.2） months）. Rapid angiographic progression of non-target lesion was angiographically assessed and the patients were classified into two groups according to whether the progression existed or not. The relation of plasma CRP levels to the progression of atherosclerosis was *** Baseline demographic, clinical, and angiographic data were similar in patients with and without *** angiographic progression of non-target lesions occurred in 136 patients （43.7%） at follow-up： 77 had a ≥10%diameter reduction of pre-existing stenosis ≥50%, 26 had a ≥30% diameter reduction of a pre-existing stenosis 〈50%, 64 developed a new lesion ≥30% in a previously normal segment, and 4 had progression of a lesion to total *** of non-target lesions was not associated with target lesion restenosis formation. High-sensitive CRP levels were markedly higher in progression patients than in non-progression ones （1.60 （0.80-3.46） mg/L vs. 0.96 （0.55-1.87）mg/L, P 〈0.001）. Multivariate regression analysis showed that plasma CRP independently predicted rapid angiographic progression of non-target lesions （P=0.001）. High-sensitive CRP levels above 1.32 mg/L （the cutoff value） were
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