The microbiome in inflammatory bowel diseases:from pathogenesis to therapy

作     者：Sheng Liu Wenjing Zhao Ping Lan Xiangyu Mou Sheng Liu;Wenjing Zhao;Ping Lan;Xiangyu Mou

作者机构：Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSchool of MedicineSun Yat-sen UniversityGuangzhou 510275China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2021年第12卷第5期

页      面：331-345页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work has been supported by National Key Research and Development Program of China(No.2017YFC1308800) the Fundamental Research Funds for the Central Universities(19ykzd33,Sun Yat-sen University) the National Natural Science Foundation of China(Grant No.31900056) 

主　　题：inflammatory bowel disease pathogenesis etiology microbiome dysbiosis therapy 

摘      要：Inflammatory bowel disease(IBD)has become a global disease with accelerating incidence worldwide in the 21st century while its accurate etiology remains *** the past decade,gut microbiota dysbiosis has consistently been associated with *** many IBDassociated dysbiosis have not been proven to be a cause or an effect of IBD,it is often hypothesized that at least some of alteration in microbiome is protective or *** this article,we selectively reviewed the hypothesis supported by both association studies in human and pathogenesis studies in biological ***,we reviewed the potential protective bacterial pathways and species against IBD,as well as the potential causative bacterial pathways and species of *** also reviewed the potential roles of some members of mycobiome and virome in ***,we covered the current status of therapeutic approaches targeting microbiome,which is a promising strategy to alleviate and cure this inflammatory disease.