Efficient and Divergent Synthesis of Medium-Sized Lactams through Zinc-Catalyzed Oxidative Cyclization of Indoly Ynamides

作     者：Hang-Hao Li Si-Han Ye Yang-Bo Chen Wen-Feng Luo Peng-Cheng Qian Long-Wu Ye Hang-Hao Li;Si-Han Ye;Yang-Bo Chen;Wen-Feng Luo;Peng-Cheng Qian;Long-Wu Ye

作者机构：State Key Laboratory of Physical Chemistry of Solid Surfaces and Key Laboratory for Chemical Biology of Fujian ProvinceCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujian 361005Chino Institute of New Materials&Industry TechnologyCollege of Chemistry&Materials EngineeringWenzhou UniversityWenzhouZhejiang 325035China State Key Laboratory of Organometallic ChemistryShanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2020年第38卷第3期

页      面：263-268页

核心收录：

学科分类：07[理学] 070304[理学-物理化学(含∶化学物理)] 0703[理学-化学] 

基　　金：the National Natu-ral Science Foundation of China(Nos.21572186,21622204 and 21772161) the Natural Science Foundation of Fujian Province of China(No.2019J02001) the President Research Funds from Xia-men University(No.20720180036) NFFTBS(No.J1310024) PCSIRT,and Science&Technology Cooperation Program of Xia-men(No.3502220183015). 

主　　题：oxidative readily sized 

摘      要：An efficient zinc-catalyzed oxidative cyclization of readily available indoly ynamides has been developed,enabling rapid and practical access to a diverse array of valuable medium-sized lactams in mostly good to excellent yields with wide substrate scope.In addition,such an asymmetric synthesis has also been explored by employing the chiral substrate.