Multiple excimer laser phototherapeutic keratectomies for Avellino corneal dystrophy:a case report

作     者：Chihiro Koiwa Satoru Nakatani Takenori Inomata Masahiro Yamaguchi Satoshi Iwamoto Akira Murakami 

作者机构：Department of OphthalmologyJuntendo University Faculty of MedicineBunyo-kuTokyo 1130033Japan Department of Strategic Operating Room Management and ImprovementJuntendo University Faculty of MedicineBunkyo-kuTokyo 1130033Japan Department of Hospital AdministrationJuntendo University Graduate School of MedicineBunkyo-kuTokyo 1130033Japan 

出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)

年 卷 期：2020年第13卷第5期

页      面：841-844页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

主　　题：laser excimer starting 

摘      要：Dear Editor,I am Chihiro Koiwa,from the Department of Ophthalmology,Juntendo University Hospital.I am writing this letter to present a case of multiple excimer laser phototherapeutic keratectomies(PTKs)for Avellino corneal dystrophy(ACD).Corneal dystrophy is a common type of hereditary,noninflammatory,and bilateral corneal disorder that involves various pathological,histological,and clinical manifestations[1].Advanced molecular gene sequencing has identified specific mutations that are associated with most dystrophies of this type.ACD,also known as granular corneal dystrophy typeⅡ[2],is autosomal dominant and associated with the R124H mutation of the transforming growth factor beta-induced(TGFBI)gene and characterized by deposits consistent with both discrete granular and lattice corneal opacities[3-4].An analysis of the TGFBI gene is essential to differentiate ACD because heterozygous R124H mutation carriers have minimal corneal abnormalities,whereas homozygotes have severe visual impairment,starting from early childhood,and early postoperative recurrence of corneal opacity.