GL-V9 reverses adriamycin resistance in hepatocellular carcinoma cells by affecting JNK2-related autophagy
GL-V9 reverses adriamycin resistance in hepatocellular carcinoma cells by affecting JNK2-related autophagy作者机构:School of Basic Medicine and Clinical PharmacologyChina Pharmaceutical UniversityNanjing 211100China Department of PharmacyCentral Hospital Affiliated to Shandong First Medical UniversityJinan 250013China
出 版 物:《Chinese Journal of Natural Medicines》 (中国天然药物(英文版))
年 卷 期:2020年第18卷第7期
页 面:491-499页
核心收录:
学科分类:0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 100706[医学-药理学] 1002[医学-临床医学] 0703[理学-化学] 100602[医学-中西医结合临床] 10[医学]
基 金:supported by the National Natural Science Foundation of China(No.81773774) “Double First-Class University Project” of China Pharmaceutical University(CPU.018GY37)
主 题:GL-V9 Drug resistance JNK2 Autophagy
摘 要:Adriamycin resistance in HCC seriously hinders the treatment of patients,it is necessary to investigate the *** is involved in adriamycin resistance and JNK2 is related to ***,whether JNK2 inducing drug resistance though autophagy is ***-V9,a new synthesized flavonoid derivative,has been proved of its anti-tumor *** aim of the study is to explore the role of JNK2-related autophagy on adriamycin-induced drug resistance and the effects of GL-V9 on reversing adriamycin *** concluded that JNK2 played an important role in drug resistance induced by *** high expression of JNK2 activated protective autophagy in Hep G2-DOXR cells under non-stress condition,which protected cells from drug ***,we found that GL-V9 reversed adriamycin resistance by blocking the JNK2-related protective autophagy in HCC.