GL-V9 reverses adriamycin resistance in hepatocellular carcinoma cells by affecting JNK2-related autophagy

作     者：YANG Yue LIAO Yan GUI Yan-Ping ZHAO Li GUO Lu-Bo YANG Yue;LIAO Yan;GUI Yan-Ping;ZHAO Li;GUO Lu-Bo

作者机构：School of Basic Medicine and Clinical PharmacologyChina Pharmaceutical UniversityNanjing 211100China Department of PharmacyCentral Hospital Affiliated to Shandong First Medical UniversityJinan 250013China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2020年第18卷第7期

页      面：491-499页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 100706[医学-药理学] 1002[医学-临床医学] 0703[理学-化学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81773774) “Double First-Class University Project” of China Pharmaceutical University(CPU.018GY37) 

主　　题：GL-V9 Drug resistance JNK2 Autophagy 

摘      要：Adriamycin resistance in HCC seriously hinders the treatment of patients,it is necessary to investigate the *** is involved in adriamycin resistance and JNK2 is related to ***,whether JNK2 inducing drug resistance though autophagy is ***-V9,a new synthesized flavonoid derivative,has been proved of its anti-tumor *** aim of the study is to explore the role of JNK2-related autophagy on adriamycin-induced drug resistance and the effects of GL-V9 on reversing adriamycin *** concluded that JNK2 played an important role in drug resistance induced by *** high expression of JNK2 activated protective autophagy in Hep G2-DOXR cells under non-stress condition,which protected cells from drug ***,we found that GL-V9 reversed adriamycin resistance by blocking the JNK2-related protective autophagy in HCC.