Torque teno virus in liver diseases: On the way towards unity of view
作者机构：Department of Propaedeutic of Internal Diseases and GastroenterologyA.I.Yevdokimov Moscow State University of Medicine and DentistryMoscow 127473Russia Central Clinical Hospital with PolyclinicPresidential Administration of the Russian FederationMoscow 121359Russia
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2020年第26卷第15期
页 面：1691-1707页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学]
主 题：Torque teno virus Prevalence of torque teno virus Torque teno virus in liver disease Virome and torque teno virus Torque teno virus and human immune status
摘 要：The review presents the data accumulated for more than 20 years of research of torque teno virus(TTV).Its molecular genetic structure,immunobiology,epidemiology,diagnostic methods,possible replication sites,and pathogenicity factors are *** is a virus that is frequently detectable in patients with different viral hepatitides,in cases of hepatitis without an obvious viral agent,as well as in a healthy *** is evidence suggesting that biochemical and histological changes occur in liver tissue and bile duct epithelium in TTV *** are sufficient histological signs of liver damage,which confirm that the virus can undergo a replicative cycle in *** with this,cytological hybridization in TTV-infected cells has shown no substantial cytopathic(cell-damaging)effects that are characteristic of pathogenic hepatotropic *** TTV has led to the evolution of views on its role in the development of human *** first ideas about the hepatotropism of the virus were gradually reformed as new data became available on the prevalence of the virus and its co-infection with other viruses,including the viruses of the known types of *** high prevalence of TTV in the human population indicates its persistence in the body as a virome and a nonpathogenic *** has recently been proposed that the level of TTV DNA in the blood of patients undergoing organ transplantation should be used as an endogenous marker of the body’s immune *** available data show the polytropism of the virus and deny the fact that TTV can be assigned exclusively to hepatitis ***,the rare detection of the damaging effect of TTV on hepatic and bile duct epithelial cells may be indirect evidence of its conditionally pathogenic *** ubiquity of the virus and the variability of its existence in humans cannot put an end to its study.
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