KIF18B promotes tumor progression in osteosarcoma by activating β-catenin

作     者：Tian Gao Ling Yu Zhiwei Fang Jiayong Liu Chujie Bai Shu Li Ruifeng Xue Lu Zhang Zhichao Tan Zhengfu Fan Tian Gao;Ling Yu;Zhiwei Fang;Jiayong Liu;Chujie Bai;Shu Li;Ruifeng Xue;Lu Zhang;Zhichao Tan;Zhengfu Fan

作者机构：Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Department of Bone and Soft Tissue TumorPeking University Cancer Hospital&InstituteBeijing 100142China Department of OrthopedicsRenmin Hospital of Wuhan UniversityWuhan 430060China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2020年第17卷第2期

页      面：371-386页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：grants from the National Natural Science Foundation of China(Grant No.81802689) China International Medical Foundation(Grant No.Z-2014-06-15331)Conflict of interest 

主　　题：β-catenin APC ATF2 KIF18B osteosarcoma 

摘      要：Objective:Osteosarcoma is a common primary highly malignant bone *** family member 18B(K1F18B)has been identified as a potential oncogene involved in the development and metastasis of several cancer *** KIF18B overexpression in osteosarcoma tissue is clearly detected,its specific function in the disease process remains to be ***:K IF18B expression was assessed in osteosarcoma tissues and *** additionally evaluated the effects of KIF18B on proliferation,migration,and invasion of osteosarcoma cells,both in vitro and in ***:Our results showed overexpression of KIF18B in osteosarcoma tissues and *** of K IF18B induced G1/S phase arrest and significantly inhibited proliferation,migration,and invasion of osteosarcoma cells,both in vitro and in vivo.K IF18B regulated P-catenin expression at the transcriptional level by controlling nuclear aggregation of ATF2 and at the post-transcriptional level by interacting with the adenomatous polyposis coli(APC)tumor suppressor gene in osteosarcoma ***:KIF18B plays a carcinogenic role in osteosarcoma by regulating expression ofβ-catenin transcriptionally via decreasing nuclear aggregation of ATF2 or post-transcriptionally through interactions with *** collective findings support the potential utility of KIF18B as a novel prognostic biomarker for osteosarcoma.