Exercise-mediated regulation of autophagy in the cardiovascular system

作     者：Lijun Wang Jiaqi Wang Dragos Cretoiu Guoping Li Junjie Xiao Lijun Wang;Jiaqi Wang;Dragos Cretoiu;Guoping Li;Junjie Xiao

作者机构：Cardiac Regeneration and Ageing LabInstitute of Cardiovascular SciencesSchool of Life ScienceShanghai UniversityShanghai 200444China Department of Cell and Molecular Biology and HistologyCarol Davila University of Medicine and PharmacyBucharest 050474Romania Alessandrescu-Rusescu National Institute of Mother and Child HealthFetal Medicine Excellence Research CenterBucharest 020395Romania Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical SchoolBostonMA 02215USA 

出 版 物：《Journal of Sport and Health Science》 (运动与健康科学（英文）)

年 卷 期：2020年第9卷第3期

页      面：203-210页

核心收录：

学科分类：0403[教育学-体育学] 1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 100216[医学-运动医学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(81722008,91639101,and 81570362 to J.Xiao,and 81800358 to L.Wang) from the Innovation Program of Shanghai Municipal Education Commission(2017-01-07-00-09-E00042 to J.Xiao) from the Science and Technology Commission of Shanghai Municipality(17010500100 and 18410722200 to J.Xiao) from the development fund for Shanghai talents(to J.Xiao) 

主　　题：Autophagy Cardiovascular diseases Exercise 

摘      要：Cardiovascular disease is the leading cause of human death worldwide. Autophagy is an evolutionarily conserved degradation pathway,which is a highly conserved cellular degradation process in which lysosomes decompose their own organelles and recycle the resulting *** is critical in maintaining cardiovascular homeostasis and function, and excessive or insufficient autophagy or autophagic flux can lead to cardiovascular disease. Enormous evidence indicates that exercise training plays a beneficial role in the prevention and treatment of cardiovascular diseases. The regulation of autophagy during exercise is a bidirectional process. For cardiovascular disease caused by either insufficient or excessive autophagy, exercise training restores normal autophagy function and delays the progression of cardiovascular *** in-depth exploration and discussion of exercise-mediated regulation of autophagy in the cardiovascular system can broaden our view about the prevention of various autophagy-related diseases through exercise training. In this article, we review autophagy and its related signaling pathways,as well as autophagy-dependent beneficial effects of exercise in cardiovascular system.