IRF4 and IRF8： governing the virtues of B lymphocytes
IRF4 and IRF8： governing the virtues of B lymphocytes作者机构：Department of Genetics Cell Biology & Anatomy University of Nebraska Medical Center Omaha NE 68198 USA
出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)
年 卷 期：2014年第9卷第4期
页 面：269-282页
核心收录：
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 090602[农学-预防兽医学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 09[农学] 0906[农学-兽医学] 071007[理学-遗传学] 0836[工学-生物工程] 0713[理学-生态学]
主 题：IRF4 IRF8 B lymphocytes transcriptional regulation leukemia and lymphoma B cell development
摘 要：Interferon regulatory factor 4 （IRF4） and IRF8 are critical regulators of immune system development and function. In B lymphocytes, IRF4 and IRF8 have been shown to control important events during their development and maturation including pre-B cell differentiation, induction of B cell tolerance pathways, marginal zone B cell development, germinal center reaction and plasma cell differentiation. Mechanistically, IRF4 and IRF8 are found to function redundantly to control certain stages of B cell development, but in other stages, they function nonredundantly to play distinct roles in B cell biology. In line with their essential roles in B cell development, deregulated expressions of IRF4 and IRF8 have been associated to the pathogenesis of several B cell malignancies and diseases. Recent studies have elucidated diverse transcriptional networks regulated by IRF4 and IRF8 at distinct B cell developmental stages and related malignancies. In this review we will discuss the recent advances for the roles of IRF4 and IRF8 during B cell development and associated diseases.
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