Maternal exercise and its beneficial effects on glucose metabolism in offspring

作     者：Jia Zheng Li-Yuan Zhou Xin-Hua Xiao Zheng Jia;Zhou Li-Yuan;Xiao Xin-Hua

作者机构：Department of EndocrinologyKey Laboratory of EndocrinologyMinistry of HealthPeking Union Medical College HospitalDiabetes Research Center of Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2020年第133卷第7期

页      面：863-867页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by grants from the National Key R&D Program of China(No.2017YFC1309603) National Key Research and Development Program of China(Nos.2016YFA0101002,2018YFC2001100) National Natural Science Foundation of China(Nos.81170736,81570715,81870579,81800703) Beijing Natural Science Foundation(Nos.7202163,7184252) Medical Epigenetics Research Center,Chinese Academy of Medical Sciences(Nos.2017PT31036,2018PT31021) Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(No.CIFMS2017-I2M-1-008) the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(Nos.2017PT32020,2018PT32001),China Diabetes Young Scientific Talent Research Project and Bethune-Merck Diabetes Research Fund of Bethune Charitable Foundation 

主　　题：Epigenetics Maternal exercise Metabolic health Offspring 

摘      要：It shows that detrimental exposures and conditions in mothers can lead to the development of obesity and type 2 diabetes in *** can lead to a vicious cycle of metabolic dysfunction,where rising rates of obesity,pre-diabetes,and diabetes in individuals of reproductive age,propagating risks to subsequent *** is well established that regular exercise has important health benefits for people with obesity and type 2 ***,increasing studies aim to examine the effects of maternal exercise on metabolic health in *** review aims to demonstrate the evidence linking maternal exercise during critical periods of development and its implications for glucose metabolism in offspring,including intervention timing,sexual dimorphism,different exercise type,and *** we further examine the potential role of epigenetic modifications in this process.