Asymmetric synthesis of pyrrolo[1,2-a]indoles via organocatalytic[3+2]annulation of substituted 2-vinylindoles with azlactones

作     者：Wulin Yang Hao Wang Zirong Pan Zhong Li Weiping Deng Wulin Yang;Hao Wang;Zirong Pan;Zhong Li;Weiping Deng

作者机构：Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of New Drug DesignSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China Shanghai Collaborative Innovation Center for Biomanufacturing TechnologyShanghai 200237China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2020年第31卷第3期

页      面：721-724页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the Fundamental Research Funds for the Central Universities the China Postdoctoral Science Foundation(Nos.2018M632037,2019T120310) Shanghai Sailing Program(No.18YF140560)。 

主　　题：[3+2]Annulation Azlactones 2-Vinylindoles Asymmetric organocatalysis Pyrrolo[1,2-a]indoles Chiral phosphoric acid 

摘      要：The chiral phosphoric acid catalyzed asymmetric[3+2]annulation of substituted 2-vinylindoles with azlactones has been established.This reaction represented a practical approach for the synthesis of structurally diverse pyrrolo[1,2-a]indoles with two vicinal stereocenters including one tetrasubstituted stereocenter in good yields and good stereoselectivities under mild conditions.