The Relationship Between the Expression of Resistin and Apoptosis Factors in Placenta and the Pathogenesis of Gestational Diabetes Mellitus

作     者：Jun Yu Xiao-Ling Su Jing Jia Yu Zeng Jing-Yi Zhang Shao-Shuai Wang Ling Feng Yu Jun;Su Xiao-Ling;Jia Jing;Zeng Yu;Zhang Jing-Yi;Wang Shao-Shuai;Feng Ling

作者机构：Department of Obstetrics and GynecologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China 

出 版 物：《Maternal-Fetal Medicine》 (母胎医学杂志（英文）)

年 卷 期：2020年第2卷第2期

页      面：80-83页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：supported by grant from the National Natural Science Foundation of China(No.41671497) 

主　　题：Diabetes,gestational Placenta Survivin Apoptosis Resistin 

摘      要：Objective::To detect the expression of caspase-3,baculoviral inhibitor of apoptosis repeat containing 5(BIRC-5),vascular endothelial growth factor(VEGF),hypoxia-inducible factor(HIF),and the concentration of resistin protein in placental of patients with gestational diabetes mellitus(GDM)and normal pregnant women,and to explore its correlation with the pathogenesis of GDM and its significance.Methods::This study includes 30 pregnant women who chose cesarean section at Tongji Hospital of Tongji Medical College during May 2013 to February 2014:15 GDM patients and 15 normal glucose tolerance patients,26-36 years old.The expression of caspase-3,VEGF,HIF,and BIRC-5 in placenta of 15 patients with GDM(GDM group)and 15 normal late pregnancy(control group)was detected by real-time fluorescence quantitative polymerase chain reaction.The concentration of resistin protein in the placenta was detected by enzyme-linked immunosorbent assay.Results::Compared with the control group,the expression of caspase-3,HIF,VEGF,resistin in placenta of GDM group increased significantly(P0.05);the expression of BIRC-5 in placenta of GDM group decreased significantly(P0.05).Conclusion::The expression of caspase-3,BIRC-5,VEGF,HIF,and resistin in placenta of GDM patients and normal pregnant women are significantly different,which may be involved in the pathogenesis of GDM disease.